Saxenda vs Ozempic in Malaysia: Which GLP-1 Is Right for You?

If you are considering GLP-1 medication for weight loss in Malaysia, you have likely come across two popular options: Saxenda and Ozempic. Both are injectable GLP-1 receptor agonists, but they differ in their active ingredients, dosing schedules, efficacy profiles, and cost. This article provides a thorough comparison to help you and your doctor decide which may be the better fit for your goals.

Overview: What Are Saxenda and Ozempic?

Saxenda contains liraglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes (marketed as Victoza). It was later approved specifically for chronic weight management and is administered as a daily injection.

Ozempic contains semaglutide, a newer GLP-1 receptor agonist also developed for type 2 diabetes. It is administered as a once-weekly injection. While Ozempic is primarily approved for diabetes, its weight-loss version (Wegovy) uses the same active ingredient at higher doses. In Malaysia, many physicians prescribe Ozempic off-label for weight management.

Side-by-Side Comparison

Dosing: Daily vs Weekly

One of the biggest practical differences is the injection frequency. Saxenda requires a daily injection, which means you need to commit to a daily routine. Some patients find this helps them stay disciplined and mindful of their treatment. Ozempic, on the other hand, is injected just once a week, which many patients find more convenient and easier to stick with long-term. If you struggle with daily medication adherence, the weekly schedule may be a significant advantage.

Weight Loss Efficacy

Clinical trials suggest that semaglutide (the active ingredient in Ozempic/Wegovy) delivers greater average weight loss compared to liraglutide (Saxenda). In the STEP trials, patients on semaglutide 2.4 mg lost an average of approximately 15% of body weight over 68 weeks, while the SCALE trials showed liraglutide patients losing around 8% of body weight over a similar period.

However, individual responses vary. Some patients respond exceptionally well to liraglutide and may not need to switch. Your doctor will help evaluate which medication aligns best with your weight loss targets and medical history.

Pricing in Malaysia

As of early 2025, Saxenda typically costs between RM 1,200 and RM 1,800 per month in Malaysia, depending on dosage and pharmacy. Ozempic generally ranges from RM 800 to RM 1,500 per month. Prices can vary depending on your clinic and whether insurance covers any portion of the cost. At Seimbang, we work to provide transparent pricing and help you understand the full cost of treatment before you start.

Side Effects Comparison

Both medications share similar gastrointestinal side effects because they act on the same GLP-1 receptor. Nausea, diarrhoea, constipation, and reduced appetite are common with both. The severity and duration tend to be comparable, though some studies suggest semaglutide may cause slightly more gastrointestinal discomfort at higher doses. In both cases, gradual dose titration is the most effective strategy for minimising side effects.

Which Is Better for Whom?

Can You Switch Between Them?

Yes. It is possible to switch from Saxenda to Ozempic (or vice versa) under medical supervision. Some patients start with one medication and switch if their response is not optimal or if they experience persistent side effects. Your Seimbang doctor will guide you through any transition safely.

The Bottom Line

Both Saxenda and Ozempic are effective GLP-1 medications that can help Malaysians achieve significant weight loss when combined with lifestyle changes. Semaglutide (Ozempic) tends to offer greater average weight loss and more convenient weekly dosing, while liraglutide (Saxenda) is specifically approved for weight management and offers a faster titration schedule. The best choice depends on your individual health profile, goals, budget, and preferences. A consultation with a licensed doctor is the best way to determine which medication is right for you.